Bicycle Therapeutics plc (BCYC)

Nasdaq · Healthcare · Biotechnology

$4.01+18.64%as of Oct 6, 2026, 4:35 AM ET

Market cap
$281M
52-week range
$3.33 – $9.16
52-week change
−58.93%
EPS (trailing)
−$2.73
Next earnings
Oct 29, 2026

Fiscal year to Dec 2025

Revenue
$72.6M (+105.77%)
Net income
−$219M
Operating margin
−340.4%
Diluted EPS
−$3.16
Free cash flow
−$252M

From the company’s annual report on SEC EDGAR.

About Bicycle Therapeutics plc

Bicycle Therapeutics plc, a clinical-stage pharmaceutical company, develops a class of medicines for diseases that are underserved by existing therapeutics in the United States and the United Kingdom. The company's products pipeline include zelenectide pevedotin, a bicycle toxin conjugate (BTC), which is in phase II clinical trials for the treatment of high nectin-4 expressing tumors; nuzefatide pevedotin (EphA2), a BTC that is in phase I/II clinical trials to treat Ephrin type A receptor 2 expressing tumor; BT7480, a Bicycle tumor-targeted immune cell agonist molecule, which is in phase I/II targeting nectin-4 and agonizing CD137; and BT1702, a theranostic BRC molecule targeting MT1-MMP for which IND-enabling activities are ongoing. In addition, it develops Novel CNS targets, which is in preclinical trial targeting CNS disease; Novel neuromuscular targets, which is in preclinical trial targeting neuromuscular disease; and programs that are in preclinical trial targeting radiopharmaceutical. Further, the company collaborates with biopharmaceutical companies and organizations to develop programs in therapeutic areas.

Headquarters: Cambridge, United Kingdom · 288 employees · bicycletherapeutics.com