Pyxis Oncology, Inc. (PYXS)

Nasdaq · Healthcare · Biotechnology

$2.24+4.67%as of Oct 6, 2026, 4:35 AM ET

Market cap
$268M
52-week range
$1.03 – $5.55
52-week change
−16.08%
EPS (trailing)
−$1.40
Analyst rating
1.3 Strong buy
Next earnings
Nov 2, 2026

Fiscal year to Dec 2025

Revenue
$13.9M (−14.17%)
Net income
−$79.6M
Operating margin
−609.2%
Diluted EPS
−$1.28
Free cash flow
−$63.5M

From the company’s annual report on SEC EDGAR.

About Pyxis Oncology, Inc.

Pyxis Oncology, Inc., a clinical stage company, engages in the development of therapeutics to treat solid tumors. Its lead antibody-drug conjugates (ADC) product candidate is PYX-201, an investigational novel ADC consisting of human immunoglobulin G1 (IgG1), which is in Phase 1 clinical trial to treat patients with relapsed or refractory solid tumors; PYX-102, an investigational immunotherapeutic targeting KLRG1, an inhibitory receptor on T cells and NK cells, with potential for use as monotherapy or in combination treatments; and lead immuno-oncology (IO) product candidate is PYX-106, an investigational fully human IgG1 Siglec-15-targeting antibody that is in Phase 1 clinical trial to treat patients with advanced solid tumors. The company is also developing PYX-107, a CD40 agonist with demonstrated anti-cancer activity in patients with several cancer indications, which is in Phase 2 clinical trial for the treatment of tumors, such as soft tissue sarcomas, esophageal and gastroesophageal junction, cancers, and pancreatic ductal adenocarcinoma. It has an in-license agreement with Pfizer Inc.

Headquarters: Boston, United States · 56 employees · pyxisoncology.com